There are already many findings about the effect of cannabidiol. The first researches in the early years came first from animal research or from investigations of clinical cell samples. However, especially in recent years, the number of available clinical studies that have tested the active substance on sick and healthy people has increased. The results of these studies and investigations allow the following statements to be scientifically substantiated.
Contrary to popular belief, CBD does not primarily bind to the classical receptors CB1 and CB2, but interacts mainly with the G protein Coupled Receptor GPR55, the Peroxisome Proliferator-Activated Receprot gamma (PPARγ) and ion channels such as the vanilloids Transient Receptor Potential Channels (TRPV1, TRPA1). CBD is a complete agonist of Transient Receptor Potential Vanilloid Type 1 (TRPV1), which plays an important role in the reaction to hot (e.g. boiling water) and harmful substances. TRPV1 is a nociceptor: When the receptor is sufficiently stimulated, signals are sent to the brain. This triggers a series of automatic reactions, including pain sensation.
Various cannabinoids, including the endocannabinoids anandamide and N-arrachidonyl dopamine (an agonist of the CB1 receptor), affect the TRPV1 receptor. Conversely, several vanilloids affect cannabinoid receptors, including olvanil and pseudocapsaicin (nonivamide), but not capsaicin itself. The close chemical relationship between many vanilloids and cannabinoids has led researchers to conclude that research into vanilloid cannabimimetics (substances that mimic cannabinoids) has great therapeutic potential.
Furthermore, CBD has been shown to act as an agonist of the 5HT1a receptor (24). This receptor controls the expression of serotonin (5HT) in the central nervous system, and this could explain many of the anxiety and depression relieving properties of CBD. CBD also has a regulating effect on the mu and delta opioid receptors, which are responsible for the anaesthetic and euphoric reaction during cannabis use, which may increase this effect in the user overall.
On CB1 and CB2 receptors (major sites of THC), CBD acts as a non-competitive nagative-allosteric modulator of CB1, CBD is neither an agonist nor an antagonist, but inhibits the binding of THC to these receptors(23). This explains the lack of psychoactive side effects and supports the thesis that CBD is the antagonist of THC in its mode of action.
1.1 CBD can be helpful in anxiety conditions (1)As one of the numerous studies shows, even small doses of CBD are sufficient to help with anxiety. A study with 49 participants showed that doses of 30mg CBD are already effective (1)
1.2 CBD can help regulate emotions and emotional memory processing (2)(3)CBD can suppress the occurrence of anxiety. Studies also show that CBD can facilitate the forgetting or repression of anxious and traumatic memories. (2)
1.3 CBD can have positive effects in unforeseen stress situations (4)In a study in stressed mice, scientists observed that CBD causes the effects on behavior due to unpredictable stress "presumably due to an alleviation of endocannabinoid neurotransmission and subsequent CB1/CB2 receptor activation".
1.4 CBD may be helpful in acute anxiety conditions (5)CBD can also be helpful in acute anxiety conditions. CBD seems to be particularly effective when anxiety is caused by negative memories. (3)
(5)Babson KA, Sottile J, Morabito D. Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Curr Psychiatry Rep. 2017 Apr;19(4):23 Link
(27)Shannon S., Opila-Lehman J.: Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report.
The Permanente Journal 2016 Case; 20(4): 108-111 Link
CBD is a relatively expensive but very potent raw material. The goal of CANNASPORT was and is to offer the athlete the optimal function with the lowest possible need for CBD. This is reflected on the one hand in our raw material, the structure of which is designed to enable maximum rapid and effective absorption in the body. In addition, we want to provide the body with the optimal framework conditions to further increase the uptake process and the effectiveness of the CBD extract. We achieve this through a unique, purely herbal combination of active ingredients. Like the CBD extract, the "ECS booster" is absorbed sublingually through the oral mucosa and sends messenger substances to the body to increase the body's cannabiniode-level (endocannabiniode-level). On the other hand, it is also intended to improve the effect and storage of the CBD drops added afterwards. This protected formula is unique and the unique selling point of CANNASPORT. For all substances used, there is extensive literature, research and studies which we would like to introduce to you in this way.
β-Caryophyllene - also called BETA-Caryophyllen, abbreviated BCP, is a natural substance found in numerous plants. Studies show that BCP is able to interact with some of the receptor sites of the endocannabiniodine system, specifically the CB2 receptor important for CBD uptake (15). Through its function as CB2 agonist, BCP also achieves its anti-inflammatory, soothing, antibacterial, antispasmodic and antioxidant effects, making it a useful supplement to CBD. The ECB-Booster contains plants melissa and dstenkraut tinctures contain this important plant substance.
Black cumin (Nigella Sativa) is one of the most studied plants due to its manifold effects. Numerous studies prove the effect of black cumin.
4.1 Black cumin as an anti-inflammatory and painkillerAlready in 1995 the anti-inflammatory and analgesic mechanism was discovered in laboratory studies (20). The thymoquinone contained in black cumin prevents the formation of eicosanoids, which are involved in the development of inflammatory processes.
4.2 Black cumin in asthmaEspecially in outdoor athletes, asthma symptoms typical of stress are not uncommon. The use of asthma sprays is always associated with a small portion of residual risk, especially for competitive athletes tested by Anti-Doping. Indian scientists tested in a study (21) over a period of three months nigella savita extract in asthma patients. Accurate analysis and lung function text showed a significant improvement in symptoms. It has also been observed that the effect of conventional asthma drugs has been improved.
4.3 Black cumin in rheumatismAlso of interest are the results of a study of black cumin oil in patients with rheumatoid arthritis (22) . In 2010, 40 patients with this diagnosis were initially treated with placebo, followed by 500 mg black cumin oil capsules twice daily. Pain and movement restrictions decreased rapidly in the treatment, in contrast to the comparative phase with the placebo: joint swelling and morning stiffness decreased, and also in the laboratory the indicator values decreased by over 40%.
Several studies have shown that alcohol increases the concentration of cannabinoids in the body and increases their effect (25)(26). We take advantage of this fact with the ECS booster. The ECS booster is based on 66 percent alcohol. Only a few drops on the oral mucosa are absorbed by the receptors. In addition to the rapid absorption of the plant substances described above, the alcohol also ensures that the CBD drops taken afterwards enter the bloodstream more quickly and in a more concentrated form. This low alcohol absorption has no effect on driving ability. 10 drops of the ECS booster are comparable to 5.4ml beer or 2.3ml wine. In addition, it should be noted that the studies listed below were primarily focused on the concentration of THC. Clinical studies in connection with alcohol and pure CBD are not yet available. However, it can be assumed that the concentration and uptake of other cannabinoids is also favored.